Search Results by Classification Category
Results for entries tagged with "Preventative Medicine"
Shock-Induced ElectroporationInternal defibrillation shock while often necessary can permanently damage the heart via disruption of cell membranes (electroporation). To study the spatial extent of cell death and tissue damage of such a shock, a coil shock electrode was inserted into the right ventricle of Langendorff-perfused rabbit heart.
Multi-modality Volumetric RegistrationSpatial registration of longitudinal volumes and subsequent analysis can enable morphometric tracking of implants to evaluate degradation/biocompatibility or assess response of various pathologies/phenotypes to therapeutics or genetic manipulation.
Micro-Computed Tomography (CT) Evaluation of Cartilage Profile using the Contrast Agent ConrayEvaluation of articular cartilage defects or delamination in small animal models for assessment of repair or response to pharmaceuticals requires both high spatial and density resolution. Unfortunately while small animal MRI systems will allow visualization cartilage, resolution is poor. While micro-computed tomography will provide the necessary resolution (as high as 1 um), soft tissue interfaces like cartilage do not attenuate well and thus are not generally visible or extremely noisy at best.
Trabecular Analysis of Rat VertebraeAlthough not loaded in the same manner as humans, vertebrae in small animals can be used to study structural changes in trabecular bone in response to various drugs and therapies for the treatment of osteoporosis if appropriate controls are in place.
Trabecular Analysis on Human Bone CoresTrabecular bone quality assessment is generally not performed in patient CT scans due to inadequate resolution, however, bone cores may be extracted from patients in non-weight bearing sites (i.e. illiac crest) or from discards obtained during implant insertion and scanned using micro-computed tomography (micro-CT) for analysis of structural indices.
Trabecular Analysis on Rat/Mouse Proximal TibiasTrabecular bone quality metrics are commonly extracted from long bones and vertebrae of ovariectomized small animal models (induces osteoporosis in mice and rats) to evaluate effectiveness of various pharmaceuticals or gene therapies in counteracting osteoporosis induced bone loss.
Automated Fundus Image AnalysisFundus photography of the eye enables visualization of the retina, optic disc, fovea, and macula. Additionally it is the only place on the body where microcirculation can be observed non-invasively. A number of pathologies can be evaluated in fundus images including diabetic retinopathy, AMD (dry and wet), various tumors, glaucoma, vascular occlusion, etc.
In-vivo Histological Bone Growth AssayTraditional methods of in-vivo bone growth evaluation in small animal models utilize longitudinal micro-CT imaging. Unfortunately, live animal imaging requires low radiation dose protocols that limit spatial resolution to ~20 um which is inadequate for small animals (particularly adults) whose bone growth rates are on the order of a few um/day.
Cell/Vessel Proximity AssaySince tumor survival is strongly dependent on vascularization, there are number of anticancer drugs that specifically target vessel growth. A subset of these drugs bind to growth factors (i.e. VEGF) and prevent them from binding to receptors that initiate angiogenesis cascades.
Adipocyte CharacterizationMorphometric analysis of fat cells or adipocytes within specific organs enables quantitative assessment of various pathologies or compounds that affect metabolic pathways. Unfortunately, most labs will perform such analysis with multiple observers manually delineating each adipocyte in a given field-of-view.
3D Vascular AnalysisContrast based vascular imaging and analysis can provide an number of key metrics for human pathology diagnosis or animal model studies including vessel occlusion, blood pressure (vessel dilation), angiogenesis (tumor formation), vascular attenuation or regression, and vascular leakage.
Cartilage Thickness in CT ArthrogramsCT arthrograms involve injection of a contrast agent into joint spaces prior to scanning to study abnormalities or tears in articulating surfaces (cartilage), tendons, ligaments, or the joint capsule as a result of injury, osteoarthritis, or other pathology. Additionally, joint contrast will clearly delineate boundaries of soft tissue that generally is weakly attenuating and noisy.
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